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Description

Despite great improvements in therapy, cardiovascular diseases are still the leading cause of death in the industrialized world. As a consequence of the ever growing progress of biomedical research, the complexity of the cellular signal transduction in the cardiovascular system is continuously growing and novel target structures for therapy development are identified continuously.

Scientists at the VRC study molecular mechanisms of physiological and pathophysiological processes in vascular cells and the vascular system at large, to uncover novel approaches to vascular disease. Special interest is placed on the signal transduction involved in new vessel formation (angiogenesis), vascular repair and differentiation, the regulation of vascular tone and blood pressure and remodeling processes such as arteriosclerosis and pulmonary hypertension. Research at the VRC particularly focusses on centrally important elements of endothelial cell biology using a broad set of techniques supported by excellent service personal.

Current work focusses on the following topics: Epigenetic signaling by histone modifications and microRNAs, Lipid signaling by cytochrome P450-derived products and their metabolizing enzymes, redox-mediated signaling by NADPH oxidases (Nox proteins) and the endothelial NO synthase, vascular mechanotransduction and calpain.

The VRC is actively involved in the programs with a cardiovascular focus at the Goethe-University, for example, the four program project grants (Sonderforschungsbereiche) of the German Research Foundation (DFG): transregio SFB/TR23 Vascular Differentiation and Remodeling, SFB 815 Redox Regulation, SFB 834 Endothelial Signaling and Vascular Repair and SFB 1039 Lipid Signalling. The VRC also participates in the Excellence Cluster Cardio-Pulmonary Systems (ECCPS) which is a joint venture between the Goethe-University, the Justus-Liebig-University in Giessen and the Max-Planck-Institute for Heart and Lung Research in Bad Nauheim. Finally, the VRC is part of the Frankfurt branch of the Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK).

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