Matthias studied Biology at the Goethe University Frankfurt and received his diplom in 2008. After an internship at the EMBL-CRG in Barcelona/Spain, he finished his PhD at the Goethe University Frankfurt in 2013 about protein co-factors of non-coding RNAs. Matthias joined the VRC as a group leader in 2012.

In 2017, he received the DZHK Postdoc startup grant and the price of the Hedwig and Heribert Eckelmann Foundation. Since 2019 he is a PI within the TRR267 (Noncoding RNA in the cardiovascular system). Matthias completed his habilitation in 2021 at the Goethe University Frankfurt. His research  focus is on long non-coding RNAs and their control of transcriptional activity through chromatin-remodelling complex recruitment with a focus on the cardiovascular system.