Goethe University Frankfurt am Main is one of the largest universities in Germany with approximately 48,000 students and 5,000 employees. Founded in 1914 by citizens of Frankfurt, Goethe University possesses a high degree of independence, modernity and subject diversity. As a comprehensive university, Goethe University Frankfurt offers more than 100 courses of study on five campuses in a total of 16 departments and at the same time has an outstanding research strength.

The Vascular Research Center Frankfurt (VRC) is currently offering the following position:

 

PhD position Veterinary Medicine

 

(m/f/x, E13, 65%, limited to 3 years with possibility of extension)

 

“Redox crosstalk in cardiovascular damage control”.

 

The Vascular Research Centre is an institute of basic biomedical research at the Department of Medicine of Goethe University, which is closely integrated into three Collaborative Research Centres, the Cardio-Pulmonary Institute (CPI) Cluster of Excellence of the Universities of Frankfurt & Giessen, along with the Max Planck Institute for Heart and Lung Research in Bad Nauheim, and the German Centre for Cardiovascular Research (DZHK). We investigate signal transduction processes in cells of the cardiovascular system and their relevance for diseases of this system. The investigations are particularly aimed at understanding and developing therapies against myocardial infarction and vascular neoplasia. A wide range of methods from cell culture and integrative physiology will be used in the course of the projects.

 

Tasks:

Cardiovascular diseases are the main cause of death in the western world. Arteriosclerosis leads to vascular occlusion. The subsequent inflammatory reaction is an important determinant of tissue damage.  Within the framework of PhD project, the significance of redox regulation in this process will be investigated using transgenic mice, among other methods. Based on a minimally invasive myocardial infarction model and a restenosis model in the mouse carotid artery, cellular reactions and dynamics will be investigated by single-cell sequencing and an accompanying analysis of redox regulation throughout the process. Assays investigating tissue damage (histology) and function (echocardiography) will be used as further readouts.

 

Qualification profile:

  • Completed studies in veterinary medicine
  • Personal commitment
  • Interest in scientific work in a team, flexibility, reliability, sense of responsibility, initiative, creativity and ability to work in a team
  • Interest in animal experiments and fine motor skills

We offer

  • An exciting, international environment in the field of basic medical research with interesting and highly relevant research projects
  • A dynamic, friendly team
  • A broad spectrum of methods
  • Participation in national and international congresses
  • Structured doctoral training
  • A varied, creative research environment and excellent facilities
  • An attractive collective agreement (TV-G-U)
  • The Hessenticket: free use of local public transport in Hesse (“Landticket”).

The position is initially limited to 3 years (with an option to extend).

Take advantage of the time to apply: please send your documents (curriculum vitae, cover letter, copies of certificates and, if applicable, references) preferably by email (jobs@vrc.uni-frankfurt.de) under the reference VetMed01 as one complete PDF to Prof. R. Brandes, Vascular Research Centre, House 74/75, 2nd floor, Department of Medicine of the Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Tel: 069-6301 85321, Internet: www.vrc.uni-frankfurt.de.