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Moretti AIS, Pavanelli JC, Nolasco P, Leisegang MS, Tanaka LY, Fernandes CG, Wosniak J Jr, Kajihara D, Dias MH, Fernandes DC, Jo H, Tran NV, Ebersberger I, Brandes RP, Bonatto D, Laurindo FRM. Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families. Sci Rep. 2017 Dec 8;7(1):17262. doi: 10.1038/s41598-017-16947-5.

Seuter S, Virtanen JK, Nurmi T, Pihlajamäki J, Mursu J, Voutilainen S, Tuomainen TP, Neme A, Carlberg C. Molecular evaluation of vitamin D responsiveness of healthy young adults. J Steroid Biochem Mol Biol. 2017 Nov;174:314-321. doi: 10.1016/j.jsbmb.2016.06.003.

Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mo, J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I (2017) Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature 552 (7684):248-252. doi: 10.1038/nature25013.

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 2017 Oct;13:94-162. doi: 10.1016/j.redox.2017.05.007.

Singh A, Koduru B, Carlisle C, Akhter H, Liu RM, Schroder K, Brandes RP, Ojcius DM. NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4. Sci Rep. 2017 Oct 30;7(1):14346. doi: 10.1038/s41598-017-14574-8.

Bibli SI, Szabo C, Chatzianastasiou A, Luck B, Zukunft S, Fleming I, Papapetropoulos A (2017) Hydrogen sulfide preserves eNOS function by inhibiting PYK2: implications for cardiomyocyte survival and cardioprotection. Mol Pharmacol 92 (6):718-730. doi: 10.1124/mol.117.109645.

Singhal RK, Kruse C, Heidler J, Strecker V, Zwicker K, Düsterwald L, Westermann B, Herrmann JM, Wittig I, Rapaport D. Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex. Mol Biol Cell. 2017 Aug 9;28(20):2609-22. doi: 10.1091/mbc.E17-02-0093.

Ilina EI, Armento A, Sanchez LG, Reichlmeir M, Braun Y, Penski C, Capper D, Sahm F, Jennewein L, Harter PN, Zukunft S, Fleming I, Schulte D, Le Guerroué F, Behrends C, Ronellenfitsch MW, Naumann U, Mittelbronn M (2017) Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget 8 (40):67567-67591. doi: 10.18632/oncotarget.18747.

Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, Frank AC, Scholich K, Pierre S, Syed SN, Olesch C, Ringleb J, Ören B, Döring C, Savai R, Jung M, von Knethen A, Levkau B, Fleming I, Weigert A, Brüne B (2017) S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β. J Exp Med 214 (9):2695-2713. doi: 10.1084/jem.20160392.

Amirjanians M, Egemnazarov B, Sydykov A, Kojonazarov B, Brandes R, Luitel H, Pradhan K, Stasch JP, Redlich G, Weissmann N, Grimminger F, Seeger W, Ghofrani H, Schermuly R. Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension. Oncotarget. 2017 May 2;8(18):29613-29624. doi: 10.18632/oncotarget.16769.

Bibli SI, Zhou Z, Zukunft S, Fisslthaler B, Andreadou I, Szabo C, Brouckaert P, Fleming I, Papapetropoulos A (2017) Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2. Cardiovasc Res 113 (8):926-937. doi: 10.1093/cvr/cvx058.

Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. 2017 Sep 6;8(1):466. doi: 10.1038/s41467-017-00503-w.

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res. 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482.

Schröder K, Weissmann N, Brandes RP. Organizers and activators: Cytosolic Nox proteins impacting on vascular function. Free Radic Biol Med. 2017 Aug;109:22-32. doi: 10.1016/j.freeradbiomed.2017.03.017.

Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646.

Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck WH, Popp R, Frömel T, Fleming I (2017) Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis. Prostaglandins Other Lipid Mediat 133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002.

Ertuna E, Loot AE, Fleming I, Yetik-Anacak G (2017) The role of eNOS on the compensatory regulation of vascular tonus by H2S in mouse carotid arteries. Nitric Oxide 69 :45-50. doi: 10.1016/j.niox.2017.04.007.

Sasaki Y, Dehnad A, Fish S, Sato A, Jiang J, Tian J, Schröder K, Brandes R, Török NJ. NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease. Sci Rep. 2017 Apr 6;7:46144. doi: 10.1038/srep46144.

Juengel E, Krueger G, Rutz J, Nelson K, Werner I, Relja B, Seliger B, Fisslthaler B, Fleming I, Tsaur I, Haferkamp A, Blaheta RA (2017) Correction: Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion. Oncotarget 8 (1):1953-1954. doi: 10.18632/oncotarget.14438.

Loroch S, Trabold K, Gambaryan S, Reiß C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K (2017) Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. Thromb Haemost 117 (3):556-569. doi: 10.1160/TH16-07-0515.

Randriamboavonjy V, Kyselova A, Elgheznawy A, Zukunft S, Wittig I, Fleming I (2017) Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice. Basic Res Cardiol 112 (1):10. doi: 10.1007/s00395-016-0596-8.

Rezende F, Prior KK, Löwe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnütgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schröder K (2017) Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays. Free Radic Biol Med 102 :57-66. doi: 10.1016/j.freeradbiomed.2016.11.019.

Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I (2017) AMP-activated protein kinase α2 in neutrophils regulates vascular repair via hypoxia-inducible factor-1α and a network of proteins Aaffecting metabolism and apoptosis. Circ Res 120 (1):99-109. doi: 10.1161/CIRCRESAHA.116.309937.

Nau C, Henrich D, Seebach C, Schröder K, Barker JH, Marzi I, Frank J. Tissue engineered vascularized periosteal flap enriched with MSC/EPCs for the treatment of large bone defects in rats. Int J Mol Med. 2017 Apr;39(4):907-917. doi: 10.3892/ijmm.2017.2901.

Pak O, Sydykov A, Kosanovic D, Schermuly RT, Dietrich A, Schröder K, Brandes RP, Gudermann T, Sommer N, Weissmann N. Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species. Adv Exp Med Biol. 2017;967:195-225. doi: 10.1007/978-3-319-63245-2_12.

Neme A, Seuter S, Carlberg C. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochim Biophys Acta Gene Regul Mech. 2017 Sep;1860(9):952-961. doi: 10.1016/j.bbagrm.2017.07.002.

de Souza AH, Santos LRB, Roma LP, Bensellam M, Carpinelli AR, Jonas JC (2017) NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice. Mol Cell Endocrinol 439:354-62. doi: 10.1016/j.mce.2016.09.022.

Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L. Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci. 2017 Mar 9;18(3):595. doi: 10.3390/ijms18030595.

Santos LRB, Muller C, de Souza AH, Takahashi HK, Spegel P, Sweet IR, Chae H, Mulder H, Jonas JC (2017) NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells. Mol Metab 6:535-47. doi: 10.1016/j.molmet.2017.04.004.

Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I. Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox Biol. 2017 Apr;11:176-191. doi: 10.1016/j.redox.2016.12.004.

Rukoyatkina N, Subramanian H, Butt E, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, and Benz PM (2017) Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis. Cell Death Dis 8:e2898. doi: 10.1038/cddis.2017.290.

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ, Brandes RP (2017) Long noncoding RNA MANTIS facilitates endothelial angiogenic function. Circulation 136:65-79. doi: 10.1161/CIRCULATIONAHA.116.026991.

Rezende F, Schürmann C, Schütz S, Harenkamp S, Herrmann E, Seimetz M, Weißmann N, Schröder K. Knock out of the NADPH oxidase Nox4 has no impact on life span in mice. Redox Biol. 2017 Apr;11:312-314. doi: 10.1016/j.redox.2016.12.012.

Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P, Hassel D (2017) Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. J Mol Cell Cardiol 108:95-105. doi: 10.1016/j.yjmcc.2017.05.011.

Fork C, Vasconez AE, Janetzko P, Angioni C, Schreiber Y, Ferreirós N, Geisslinger G, Leisegang MS, Steinhilber D, Brandes RP. Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300. J Lipid Res. 2017 Feb;58(2):386-392. doi: 10.1194/jlr.M072280.

Spieker J, Mudersbach T, Vogel-Hopker A, Layer PG (2017) Endochondral ossification is accelerated in cholinesterase-deficient mice and in avian mesenchymal micromass cultures. PLoS ONE 12:e0170252. doi: 10.1371/journal.pone.0170252.

Siragusa M, Fisslthaler B (2017) Insulin keeps PYK-ing on eNOS: enhanced insulin receptor signaling induces endothelial dysfunction. Circ Res 120:748-50.Fleming I, Meens MJ, Kwak BR. The endothelial cell. In: Krams R, Bäck M, eds. (2017) The ESC Textbook of Vascular Biology. Oxford University Press p. 73-90. doi: 10.1161/CIRCRESAHA.117.310576.

Seuter S, Neme A, Carlberg C. Epigenomic PU.1-VDR crosstalk modulates vitamin D signaling. Biochim Biophys Acta Gene Regul Mech. 2017 Apr;1860(4):405-415. doi: 10.1016/j.bbagrm.2017.02.005.

Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S. A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ. 2017 Jan;24(1):83-97. doi: 10.1038/cdd.2016.102.

Dosoki H, Stegemann A, Taha M, Schnittler H, Luger TA, Schröder K, Distler JH, Kerkhoff C, Böhm M. Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Exp Dermatol. 2017 Jan;26(1):73-81. doi: 10.1111/exd.13180.