2018

Namgaladze, D, Zukunft, S, Schnütgen, F, Kurrle, N, Fleming, I, Fuhrmann, D, Brüne, B (2018) Polarization of human macrophages by interleukin-4 does not require ATP-citrate lyase. Front Immunol 9 :2858. doi: 10.3389/fimmu.2018.02858.

 

Riddell, M, Nakayama, A, Hikita, T, Mirzapourshafiyi, F, Kawamura, T, Pasha, A, Li, M, Masuzawa, M, Looso, M, Steinbacher, T, Ebnet, K, Potente, M, Hirose, T, Ohno, S, Fleming, I, Gattenlöhner, S, Aung, PP, Phung, T, Yamasaki, O, Yanagi, T, Umemura, H, Nakayama, M (2018) aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nat Commun 9 (1):5357. doi: 10.1038/s41467-018-07739-0.

 

Nau C, Simon S, Schaible A, Seebach C, Schröder K, Marzi I, Henrich D. Influence of the induced membrane filled with syngeneic bone and regenerative cells on bone healing in a critical size defect model of the rat’s femur. Injury. 2018 Oct;49(10):1721-1731. doi: 10.1016/j.injury.2018.06.041.

 

Zippel N, Loot AE, Stingl H, Randriamboavonjy V, Fleming, I, Fisslthaler, B (2018) Endothelial AMP-activated kinase α1 phosphorylates eNOS on Thr495 and decreases endothelial NO formation. Int J Mol Sci 19 (9):. doi: 10.3390/ijms19092753.

 

Randriamboavonjy V, Fleming I (2018) Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs. Clin Sci (Lond) 132 (17):1875-1888. doi: 10.1042/CS20180580.

 

Bibli SI, Luck B, Zukunft S, Wittig J, Chen W, Xian M, Papapetropoulos A, Hu J, Fleming I (2018) A selective and sensitive method for quantification of endogenous polysulfide production in biological samples. Redox Biol 18 :295-304. doi: 10.1016/j.redox.2018.07.016.

 

Helfinger V, Schröder K. Redox control in cancer development and progression. Mol Aspects Med. 2018 Oct;63:88-98. doi: 10.1016/j.mam.2018.02.003.

 

Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M. PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. EMBO Rep. 2018 Sep;19(9):e45253. doi: 10.15252/embr.201745253

 

Frauscher B, Kirsch AH, Schabhüttl C, Schweighofer K, Kétszeri M, Pollheimer M, Dragun D, Schröder K, Rosenkranz AR, Eller K, Eller P. Autophagy Protects From Uremic Vascular Media Calcification. Front Immunol. 2018 Aug 14;9:1866. doi: 10.3389/fimmu.2018.01866.

 

Moll F, Walter M, Rezende F, Helfinger V, Vasconez E, De Oliveira T, Greten FR, Olesch C, Weigert A, Radeke HH, Schröder K. NoxO1 Controls Proliferation of Colon Epithelial Cells. Front Immunol. 2018 May 8;9:973. doi: 10.3389/fimmu.2018.00973.

 

Nicolay JP, Thorn V, Daniel C, Amann K, Siraskar B, Lang, F, Hillgruber C, Goerge T, Hoffmann S, Gorzelanny C, Huck V, Mess C, Obser T, Schneppenheim R, Fleming I, Schneider MF, Schneider SW (2018) Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy. Sci Rep 8 (1):10945. doi: 10.1038/s41598-018-28961-2.

 

Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V (2018) Alpha-1 antitrypsin inhibits ATP-mediated release of interleukin-1β via CD36 and nicotinic acetylcholine receptors. Front Immunol 9 :877. doi: 10.3389/fimmu.2018.00877.

 

Brandes RP. Stay in Shape With BH4: Loss of Endothelial Tetrahydrobiopterin Promotes Aortic Aneurysm Development in Mice. 2018 Hypertension. Jul;72(1):61-62. doi: https://doi.org/10.1161/hypertensionaha.118.11295.

 

Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D. A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages. Vascul Pharmacol. 2018 Apr;103-105:16-28. doi: 10.1016/j.vph.2018.01.005.

 

Brandes RP, Rezende F, Schröder K. Redox Regulation Beyond ROS: Why ROS Should Not Be Measured as Often. Circ Res. 2018 Jul 20;123(3):326-328. doi: 10.1161/CIRCRESAHA.118.313146.

 

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP (2018) Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Commun 9 (1):2292. doi: 10.1038/s41467-018-04602-0.

 

Hu, J, Frömel, T, Fleming, I (2018) Angiogenesis and vascular stability in eicosanoids and cancer. Cancer Metastasis Rev 37 (2-3):425-438. doi: 10.1007/s10555-018-9732-2.

 

Cencioni C, Spallott, F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehag, M, Sürün D, Siragusa M, Smith JG, Schnütgen F, von Melchner H, Rieger MA, Martelli F, Riccio A, Fleming I, Braun T, Zeiher AM, Farsetti A, Gaetano C (2018) Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells. Nat Commun 9 (1):1281. doi:10.1038/s41467-018-03668-0.

 

Leisegang MS, Schröder K, Brandes RP. Redox Regulation and Noncoding RNAs. Antioxid Redox Signal. 2018 Sep 20;29(9):793-812. doi: 10.1089/ars.2017.7276.

 

Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M.Elife. Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. 2018 Dec 27;7:e41044. doi: 10.7554/eLife.41044.

 

Kohlstedt K, Trouvain C, Frömel T, Mudersbach T, Henschler R, Fleming, I (2018) Role of the angiotensin-converting enzyme in the G-CSF-induced mobilization of progenitor cells. Basic Res Cardiol 113 (3):18. doi: 10.1007/s00395-018-0677-y.

 

Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, Abdel Malik R, Bothur S, Wingert S, Bremer R, Rieger MA, Brüne B, Brandes RP, Fleming I, Benz PM (2018) VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia. J Cell Biol 217 (4):1503-1519. doi: 10.1083/jcb.201702048.

 

Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D (2018) Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses. Biochim Biophys Acta Mol Cell Biol Lipids 1863 (4):433-446. doi: 10.1016/j.bbalip.2018.01.009.

 

Zukunft S, Prehn C, Röhring C, Möller G, Hrabě de Angelis M, Adamski J, Tokarz J (2018) High-throughput extraction and quantification method for targeted metabolomics in murine tissues. Metabolomics 14 (1):18. doi: 10.1007/s11306-017-1312-x.

 

Köhler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja TF, Straub A, Benz PM, Rosenberger P (2018) Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning. Basic Res Cardiol 113 (2):11. doi: 10.1007/s00395-018-0667-0.

 

Rezende F, Moll, F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K (2018) The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice. Redox Biol 15 :12-21. doi: 10.1016/j.redox.2017.11.014.

 

Spallotta, F, Cencioni, C, Atlante, S, Garella, D, Cocco, M, Mori, M, Mastrocola, R, Kuenne, C, Guenther, S, Nanni, S, Azzimato, V, Zukunft, S, Kornberger, A, Sürün, D, Schnütgen, F, von Melchner, H, Di Stilo, A, Aragno, M, Braspenning, M, van Criekinge, W, De Blasio, MJ, Ritchie, RH, Zaccagnini, G, Martelli, F, Farsetti, A, Fleming, I, Braun, T, Beiras-Fernandez, A, Botta, B, Collino, M, Bertinaria, M, Zeiher, AM, Gaetano, C (2018) Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from type2 diabetes patients: rescue by α-ketoglutarate and TET-TDG functional reactivation. Circ Res 122 (1):31-46. Doi: 10.1161/CIRCRESAHA.117.311300.

 

Janko M, Sahm J, Schaible A, Brune JC, Bellen M, Schroder K, Seebach C, Marzi I, Henrich D.  Comparison of three different types of scaffolds preseeded with human bone marrow mononuclear cells on the bone healing in a femoral critical size defect model of the athymic rat. J Tissue Eng Regen Med. 2018 Mar;12(3):653-666. doi: 10.1002/term.2484.

 

Gupta S, Jain A, Syed SN, Snodgrass RG, Pflüger-Müller B, Leisegang MS, Weigert A, Brandes RP, Ebersberger I, Brüne B, Namgaladze D. IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors. Oncoimmunology. 2018 Jul 30;7(10):e1494110. doi: 10.1080/2162402X.2018.1494110.

 

Jiménez-Altayó F, Meirelles T, Crosas-Molist E, Sorolla MA, Del Blanco DG, López-Luque J, Mas-Stachurska A, Siegert AM, Bonorino F, Barberà L, García C, Condom E, Sitges M, Rodríguez-Pascual F, Laurindo F, Schröder K, Ros J, Fabregat I, Egea G. Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm. Free Radic Biol Med. 2018 Apr;118:44-58. doi: 10.1016/j.freeradbiomed.2018.02.023.

 

 

Josipovic I, Pflüger B, Fork C, Vasconez AE, Oo JA, Hitzel J, Seredinski S, Gamen E, Heringdorf DMZ, Chen W, Looso M, Pullamsetti SS, Brandes RP, Leisegang MS. Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function. J Mol Cell Cardiol. 2018 Mar;116:57-68. doi: 10.1016/j.yjmcc.2018.01.015.

 

Rezende F, Brandes RP, Schröder K. Detection of Hydrogen Peroxide with Fluorescent Dyes. Antioxid Redox Signal. 2018 Aug 20;29(6):585-602. doi: 10.1089/ars.2017.7401.

 

Elgheznawy A, Fleming I (2018) Platelet-enriched microRNAs and cardiovascular homeostasis. Antioxid Redox Signal 29 (9):902-921. doi: 10.1089/ars.2017.7289

 

Eresch J, Stumpf M, Koch A, Vutukuri R, Ferrrirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Hattenbach L-O, Pfeilschifter J, Pfeilschifter W. (2018) Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Opthamol Vis Sci. 59 (2):653-61. Doi: 10.1167/iovs.17-22544.

 

Epah J, Pálfi K, Dienst FL, Malacarne PF, Bremer R, Salamon M, Kumar S, Jo H, Schürmann C, Brandes RP. 3D Imaging and Quantitative Analysis of Vascular Networks: A Comparison of Ultramicroscopy and Micro-Computed Tomography. Theranostics. 2018 Mar 7;8(8):2117-2133. doi: 10.7150/thno.22610.

 

Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C (2018) Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells. Sci. Rep. 8:914. doi: 10.1038/s41598-018-19216-1.

 

Bie P, Brandes RP, Deuchars SA, Eisner DA, Fandrey J, Hecker M, Louch WE, Taira T, Yilmaz B. Bringing European physiologists together. Europhysiology Organizing Committee.Acta Physiol (Oxf). 2018 Apr;222(4):e13043. doi: 10.1111/apha.13043.

 

Glynos C, Bibli SI, Katsaounou P, Pavlidou A, Magkou C, Karavana V, Topouzis S, Kalomenidis I, Zakynthinos SG, Papapetropoulos A (2018) Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 315:L662-L672. doi: 10.1152/ajplung.00389.2017

 

Hansen JB, Dos Santos LRB, Liu Y, Prentice KJ, Teudt F, Tonnesen M, Jonas JC, Wheeler MB, Mandrup-Poulsen T (2018) Glucolipotoxic conditions induce beta-cell iron import, cytosolic ROS formation and apoptosis. J Mol Endocrinol. 61:69-77. doi:10.1530/JME-17-0262.

 

Zhang M, Mongue-Din H, Martin D, Catibog N, Smyrnias I, Zhang X, Yu B, Wang M, Brandes RP, Schröder K, Shah AM. Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling. Cardiovasc Res. 2018 Mar 1;114(3):401-408. doi: 10.1093/cvr/cvx204.

 

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N. Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension. Eur Respir J. 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017.

 

Rebelato E, Santos LR, Carpinelli AR, Rorsman P, Abdulkader F. (2018) Short-term high glucose culture potentiates pancreatic beta cell function. Sci Rep. 8:13061. doi: 10.1038/s41598-018-31325-5.

 

El-Battrawy I, Zhao Z, Lan H, Li X, Yucel G, Lang S, Sattler K, Schunemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Muller OJ, Akin I (2018) Ion channel dysfunctions in dilated cardiomyopathy in limb-girdle mMuscular dystrophy. Circ Genom Precis Med. 11:e001893. doi: 10.1161/CIRCGEN.117.001893.