2019

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP. The polarity protein Scrib limits atherosclerosis development in mice. Cardiovasc Res. 2019 Dec 1;115(14):1963-1974. doi: 10.1093/cvr/cvz093https://doi.org/10.1093/cvr/cvz093.

 

Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR (2019) Coronary revascularization during heart regeneration is regulated by epicardial and endocardial cues and forms a scaffold for cardiomyocyte repopulation. Dev Cell 51 (4):503-515.e4. doi: 10.1016/j.devcel.2019.10.019

 

Fink AF, Ciliberti G, Popp R, Sirait-Fischer E, Frank AC, Fleming I, Sekar D, Weigert A, Brüne B (2019) IL27Rα deficiency alters endothelial cell function and subverts tumor angiogenesis in mammary carcinoma. Front Oncol 9 :1022. doi: 10.3389/fonc.2019.01022.

 

Raimann FJ, Dröse S, Bonke E, Schneider L, Tybl E, Wittig I, Heidler J, Heide H, Josipovic I, Leisegang M, Brandes RP, Roeper J, Zacharowski K, Mersmann J. TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion. J Cardiovasc Transl Res. 2019 Oct;12(5):478-487. doi: 10.1007/s12265-019-09887-0.

 

Siuda D, Randriamboavonjy V, Fleming I (2019) Regulation of calpain 2 expression by miR-223 and miR-145. Biochim Biophys Acta Gene Regul Mech 1862 (10):194438. doi: 10.1016/j.bbagrm.2019.194438.

 

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim JI, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E (2019) Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice. Blood 134 (17):1469-1479. doi: 10.1182/blood.2019001392.

 

Hu J, Bibli SI, Wittig J, Zukunft S, Lin J, Hammes HP, Popp R, Fleming I (2019) Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity. J Clin Invest 129 (12):5204-5218. doi: 10.1172/JCI123835.

 

Schröder K. NADPH oxidases in bone homeostasis and osteoporosis. Free Radic Biol Med. 2019 Feb 20;132:67-72. doi: 10.1016/j.freeradbiomed.2018.08.036.

 

Fleming I (2019) New lipid mediators in retinal angiogenesis and retinopathy. Front Pharmacol 10 :739. doi: 10.3389/fphar.2019.00739

 

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I (2019) Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition. EMBO J 38 (17):e100938. doi: 10.15252/embj.2018100938.

 

Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I (2019) Myeloid-specific deletion of the AMPKα2 subunit alters monocyte protein expression and atherogenesis. Int J Mol Sci 20 (12):. doi: 10.3390/ijms20123005.

 

Leisegang MS, Bibli SI, Günther S, Pflüger-Müller B, Oo JA, Höper C, Seredinski S, Yekelchyk M, Schmitz-Rixen T, Schürmann C, Hu J, Looso M, Sigala F, Boon RA, Fleming I, Brandes RP (2019) Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS. Eur Heart J 40 (30):2523-2533. doi: 10.1093/eurheartj/ehz393.

 

Bräutigam J, Bischoff I, Schürmann C, Buchmann G, Epah J, Fuchs S, Heiss E, Brandes RP, Fürst R. Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2. J Mol Cell Cardiol. 2019 Oct;135:97-108. doi: 10.1016/j.yjmcc.2019.08.001.

 

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S (2019) Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest 129 (7):2775-2791. doi: 10.1172/JCI123825.

 

Mudersbach T, Siuda D, Kohlstedt K, Fleming I (2019) Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation. PLoS One 14 (5):e0216218. doi: 10.1371/journal.pone.0216218.

 

Fuhrmann DC, Olesch C, Kurrl, N, Schnütgen F, Zukunft S, Fleming I, Brüne B (2019) Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins. Cells 8 (2):. doi: 10.3390/cells8020172.

 

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H (2019) ADAR1 is required for dendritic cell subset homeostasis and alveolar macrophage function. J Immunol 202 (4):1099-1111. doi: 10.4049/jimmunol.1800269.

 

von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis. Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057.

 

Kyselova A, Hinrichsmeyer H, Zukunft S, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V (2019) Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome. Metabolism 90 :16-19. doi: 10.1016/j.metabol.2018.10.008.

 

Randriamboavonjy V, Kyselova A, Fleming I (2019) Redox-regulation of calpain and its consequence for vascular function. Antioxid Redox Signal 30 (7):1011-1026. doi: 10.1089/ars.2018.7607.

 

Bibli SI, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steve, S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I (2019) Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug. Cardiovasc Res 115 (3):625-636. doi: 10.1093/cvr/cvy222.

 

Helfinger V, Palfi K, Weigert A, Schröder K. The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner..Oxid Med Cell Longev. 2019 Apr 18;2019:3264858. doi: 10.1155/2019/3264858.

 

Leisegang MS, Gu L, Preussner J, Günther S, Hitzel J, Ratiu C, Weigert A, Chen W, Schwarz EC, Looso M, Fork C, Brandes RP. The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G. FEBS Lett. 2019 Mar;593(5):487-498. doi: 10.1002/1873-3468.13337.

 

Gimenez M, Veríssimo-Filho S, Wittig I, Schickling BM, Hahner F, Schürmann C, Netto LES, Rosa JC, Brandes RP, Sartoretto S, De Lucca Camargo L, Abdulkader F, Miller FJ Jr, Lopes LR. Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):224-236. doi: 10.1161/ATVBAHA.118.311038.

 

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I (2019) Cystathionine γ lyase sulfhydrates the RNA binding protein human antigen R to preserve endothelial cell function and delay atherogenesis. Circulation 139 (1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.

Ullrich M, Assmus B, Augustin AM, Habich H, Abesser M, Martin MJ, Werner F, Erkens R, Arias-Loza AP, Umbenhauer S, Wagner H, Benz PM, Unger A, Linke WA, Frantz S, Baba HA, Kuhn M, Schuh K. (2019) SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy. J Mol Cell Cardiol 129:13-26 doi: 10.1016/j.yjmcc.2019.01.023 .

 

Schröder K. Redox Control of Angiogenesis. Antioxid Redox Signal. 2019 Mar 1;30(7):960-971. doi: 10.1089/ars.2017.7429.

 

Fleming I. (2019) Herzgesundheit: Du bist, was du isst! Über den Einfluss von Diäten, Nahrungsergänzungsmitteln und Probiotika. von Herzen. 2.2019 ed. 2019. p. 12-5.

 

Schröder K. NADPH oxidase-derived reactive oxygen species: Dosis facit venenum. Exp Physiol. 2019 Apr;104(4):447-452. doi: 10.1113/EP087125.

 

Löwe O, Rezende F, Heidler J, Wittig I, Helfinger V, Brandes RP, Schröder K. BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4. Redox Biol. 2019 Feb;21:101125. doi: 10.1016/j.redox.2019.101125.

 

Nurminen V, Seuter S, Carlberg C.  Primary Vitamin D Target Genes of Human Monocytes. Front Physiol. 2019 Mar 5;10:194. doi: 10.3389/fphys.2019.00194.

 

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L. Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int. 2019 Mar;95(3):540-562. doi: 10.1016/j.kint.2018.10.037.

 

Bahlmann O, Schürmann C, Maronde E. Altered laryngeal morphology in Period1 deficient mice. Ann Anat. 2019 May;223:43-48. doi: 10.1016/j.aanat.2019.01.009.

 

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS (2019) The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3’UTR of soluble epoxide hydrolase. Acta Physiol (Oxf) 225 (1):e13168. doi: 10.1111/apha.13168.

 

Nurminen V, Neme A, Seuter S, Carlberg C. Modulation of vitamin D signaling by the pioneer factor CEBPA. Biochim Biophys Acta Gene Regul Mech. 2019 Jan;1862(1):96-106. doi: 10.1016/j.bbagrm.2018.12.004.

 

Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm HE. The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses. Sci Rep. 2019 Feb 8;9(1):1718. doi: 10.1038/s41598-018-37222-1.

 

Poveda-Huertes D, Matic S, Marada A, Habernig L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, Vögtle FN. An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates. Mol Cell. 2020 Jan 2;77(1):180-188.e9. doi: 10.1016/j.molcel.2019.09.026.