2020

Kyselova A, Elgheznawy A, Wittig I, Heidler J, Mann AW, Ruf W, Fleming I, Randriamboavonjy V (2020) Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes. Basic Res Cardiol 115 (6):75. doi: 10.1007/s00395-020-00833-9.

 

Lother A, Bondareva O, Saadatmand AR, Pollmeier L, Härdtner C, Hilgendorf I, Weichenhan D, Eckstein V, Plass C, Bode C, Backs J, Hein L, Gilsbach R. Diabetes changes gene expression but not DNA methylation in cardiac cells. J Mol Cell Cardiol. 2021 Feb;151:74-87. doi: 10.1016/j.yjmcc.2020.11.004.

 

Mamazhakypov A, Weiß A, Zukunft S, Sydykov A, Kojonazarov B, Wilhelm J, Vroom C, Petrovic A, Kosanovic D, Weissmann N, Seeger W, Fleming I, Iglarz M, Grimminger F, Ghofrani HA, Pullamsetti SS, Schermuly RT (2020) Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats. Pulm Circ 10 (4):2045894020947283. doi: 10.1177/2045894020947283.

 

Oo JA, Irmer B, Günther S, Warwick T, Pálfi K, Izquierdo Ponce J, Teichmann T, Pflüger-Müller B, Gilsbach R, Brandes RP, Leisegang MS. ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting. Sci Rep. 2020 Nov 5;10(1):19079. doi: 10.1038/s41598-020-76193-0.

 

Brandes RP, Oo JA, Leisegang MS (2020) Thymosin beta-4x LINCs SPAAR to its non-coding function. Cardiovasc Res 2020 Oct 1. doi: 10.1093/cvr/cvaa098.

 

Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V (2020) Cyclin Y is expressed in platelets and modulates integrin outside-in signaling. Int J Mol Sci 21 (21):8239. doi: 10.3390/ijms21218239.

 

Buchmann GK, Schürmann C, Warwick T, Schulz MH, Spaeth M, Müller OJ, Schröder K, Jo H, Weissmann N, Brandes RP (2020).  Deletion of NoxO1 limits atherosclerosis development in female mice. Redox Biol. 2020 Oct;37:101713. doi: 10.1016/j.redox.2020.101713.

 

Buchmann GK, Schürmann C, Warwick T, Schulz MH, Spaeth M, Müller OJ, Schröder K, Jo H, Weissmann N, Brandes RP. Deletion of NoxO1 limits atherosclerosis development in female mice. Redox Biol. 2020 Oct;37:101713. doi: 10.1016/j.redox.2020.101713.

 

Schader T, Löwe O, Reschke C, Malacarne P, Hahner F, Müller N, Gajos-Draus A, Backs J, Schröder K. Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells. Redox Biol. 2020 Sep;36:101669. doi: 10.1016/j.redox.2020.101669.

 

Huang J, Huth C, Covic M, Troll M, Adam J, Zukunft S, Prehn C, Wang L, Nano J, Scheerer MF, Neschen S, Kastenmüller G, Suhre K, Laxy M, Schliess F, Gieger C, Adamski J, Hrabe de Angelis M, Peters A, Wang-Sattler R (2020) Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes. Diabetes 69 (12):2756-2765. doi: 10.2337/db20-0586.

 

Lin J, Hu J, Schlotterer A, Wang J, Kolibabka M, Awwad K, Dietrich N, Breitschopf K, Wohlfart P, Kannt A, Lorenz K, Feng Y, Popp R, Hoffmann S, Fleming I, Hammes HP (2020) Protective effect of soluble epoxide hydrolase inhibition in retinal vasculopathy associated with polycystic kidney disease. Theranostics 10 (17):7857-7871. doi: 10.7150/thno.43154.

 

Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020 Jun;2(6):532-546. doi: 10.1038/s42255-020-0215-8.

 

Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020 Jul;2(7):648. doi: 10.1038/s42255-020-0248-z.

 

Siragusa M, Justo AFO, Malacarne PF, Strano A, Buch A, Withers B, Peters KG, Fleming I (2020) VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes. Cardiovasc Res :cvaa213. doi: 10.1093/cvr/cvaa213.

 

Leiblein M, Koch E, Winkenbach A, Schaible A, Nau C, Büchner H, Schröder K, Marzi I, Henrich D. Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet’s induced membrane in a critical size defect model in the rat’s femur. J Biomed Mater Res B Appl Biomater. 2020 May;108(4):1469-1482. doi: 10.1002/jbm.b.34495.

 

Plecitá-Hlavatá L, Jabůrek M, Holendová B, Tauber J, Pavluch V, Berková Z, Cahová M, Schröder K, Brandes RP, Siemen D, Ježek P. Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4. Diabetes. 2020 Jul;69(7):1341-1354. doi: 10.2337/db19-1130.

 

Hesse M, Bednarz R, Carls E, Becker C, Bondareva O, Lother A, Geisen C, Dreßen M, Krane M, Roell W, Hein L, Fleischmann BK, Gilsbach R. Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. J Mol Cell Cardiol. 2021 Mar;152:95-104. doi: 10.1016/j.yjmcc.2020.11.012.

 

Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S (2020) Adipocyte piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun 11 (1):2303. doi: 10.1038/s41467-020-16026-w.

 

Kesavan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I (2020) Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer. Proc Natl Acad Sci U S A 117 (11):5923-5930. doi: 10.1073/pnas.1921381117.

 

Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A (2020) Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. Biochem Pharmacol 176 :113833. doi: 10.1016/j.bcp.2020.113833.

 

Dos Santos LRB, Fleming I (2020) Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome. Prostaglandins Other Lipid Mediat 148 :106407. doi: 10.1016/j.prostaglandins.2019.106407.

 

Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I (2020) Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol 28 :101379. doi: 10.1016/j.redox.2019.101379.

 

Perez RE, Basu A, Nabit BP, Harris NA, Folkes OM, Patel S, Gilsbach R, Hein L, Winder DG. α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference. Neuropsychopharmacology. 2020 Aug;45(9):1473-1481. doi: 10.1038/s41386-020-0641-z.

 

Hoelscher SC, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler SA. miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations. Int J Mol Sci. 2020 Feb 10;21(3):1158. doi: 10.3390/ijms21031158.

 

Wolff J, Rabbani L, Gilsbach R, Richard G, Manke T, Backofen R, Grüning BA. Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization. Nucleic Acids Res. 2020 Jul 2;48(W1):W177-W184. doi: 10.1093/nar/gkaa220.

 

Pflüger-Müller B, Oo JA, Heering J, Warwick T, Proschak E, Günther S, Looso M, Rezende F, Fork C, Geisslinger G, Thomas D, Gurke R, Steinhilber D, Schulz M, Leisegang MS, Brandes RP. The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells. Basic Res Cardiol. 2020 Apr 22;115(3):34. doi: 10.1007/s00395-020-0793-3.

 

Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020 Apr 27;11(1):2039. doi: 10.1038/s41467-020-15995-2.

 

Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I (2020) AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting. Acta Physiol (Oxf) 228 (1):e13325. doi: 10.1111/apha.13325.

 

Vellecco V, Martelli A, Bibli IS, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Basso EM, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G (2020) Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. Br J Pharmacol 177 (4):810-823. doi: 10.1111/bph.14700.

 

Govar AA , Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos S, Módis K (2020) 3‐Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. Br J Pharmacol. 177(4): 866–883. doi: 10.1111/bph.14574 .

 

Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, and Sessa WC (2020) Unbiased proteomics identifies plasminogen activatorinhibitor-1 as a negative regulator of endothelial nitricoxide synthase. PNAS April 28, 2020 117 (17) 9497-9507; doi: 10.1073/pnas.1918761117.