Sulfhydromics for vascular function
Hydrogen sulfide (H2S) is widely considered as a toxic gas. However, over the past 10 years H2S has been identified as a new endogenous gaseous signaling molecule with a wide range of physiological functions. Mechanistically, only the past 2 years has become clear how the H2S could function to affect cellular processes. Our team was able to establish novel methodologies to analyze the molecular functions of H2S. By mapping the first endothelial cell S-sulfhydrome (unbiased identification of cysteine residues modified by H2S in a process term S-sulfhydration) it was evident that such post-translational modifications impact on vessel function. Currently, we are investigating the mechanisms driving the dynamics of S-sulfhydration that control endothelial cell fate decisions in health and diseases. Our aim is to unravel novel targets currying sulfur related modifications that can be used as novel therapies to preserve vascular function.
Prof. Dr. Iris-Sofia Bibli