Latest Publications

2022

Veith C, Vartürk-Özcan I, Wujak M, Hadzic S, Wu CY, Knoepp F, Kraut S, Petrovic A, Gredic M, Pak O, Brosien M, Heimbrodt M, Wilhelm J, Weisel FC, Malkmus K, Schäfer K, Gall H, Tello K, Kosanovic D, Sydykov A, Sarybaev A, Günther A, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Kwapiszewska G, Sommer N, Weissmann N. Circulation. SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension. 2022 Mar 22;145(12):916-933. doi: 10.1161/CIRCULATIONAHA.121.057001. Epub 2022 Feb 17.PMID: 35175782

 

Oo JABrandes RP, Leisegang MS. Long non-coding RNAs: novel regulators of cellular physiology and function. Pflugers Arch. 2022 Feb;474(2):191-204. doi: 10.1007/s00424-021-02641-z. Epub 2021 Nov 18.PMID: 34791525 
 
Brandes RP, Gründer S. Europhysiology 2022: bringing together the physiologists of Europe and the World : 16-18 September 2022, Tivoli Congress Center, Copenhagen, Denmark” as subtitle. Pflugers Arch. 2022 May;474(5):481-482. doi: 10.1007/s00424-022-02676-w.PMID: 35253088
 
Gredic M, Wu CY, Hadzic S, Pak O, Savai R, Kojonazarov B, Doswada S, Weiss A, Weigert A, Guenther A, Brandes RP, Schermuly RT, Grimminger F, Seeger W, Sommer N, Kraut S, Weissmann N. Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice. Eur Respir J. 2022 Apr 7;59(4):2101153. doi: 10.1183/13993003.01153-2021. Print 2022 Apr.PMID: 34475225 

Pliquett RU, Brandes RP. Experimental uninephrectomy associates with less parasympathetic modulation of heart rate and facilitates sodium-dependent arterial hypertension. PLoS One. 2022 Mar 9;17(3):e0265086. doi: 10.1371/journal.pone.0265086. eCollection 2022. PMID: 35263383 
 
Seredinski S, Boos F, Günther S, Oo JA, Warwick T, Izquierdo Ponce J, Lillich FF, Proschak E, Knapp S, Gilsbach R, Pflüger-Müller B, Brandes RP, LeisegangMS. DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells. Mol Ther Nucleic Acids. 2022 Jan 25;27:1023-1035. doi: 10.1016/j.omtn.2022.01.016. eCollection 2022 Mar 8.PMID: 35228897 

Warwick T, Schulz MH, Gilsbach RBrandes RP, Seuter S. Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763. doi: 10.1093/nar/gkac178. PMID: 35325193
 

2021

Lopez M, Malacarne PF, Gajos-Draus A, Ding X, Daiber A, Lundberg JO, Offermanns S, Brandes RP, Rezende F. Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. Br J Pharmacol. 2021 Apr;178(7):1495-1506. doi: 10.1111/bph.15362.

 

Monteiro JP, Rodor J, Caudrillier A, Scanlon JP, Spiroski AM, Dudnakova T, Pflüger-Müller B, Shmakova A, von Kriegsheim A, Deng L, Taylor RS, Wilson-Kanamori JR, Chen SH, Stewart K, Thomson A, Mitić T, McClure JD, Iynikkel J, Hadoke PWF, Denby L, Bradshaw AC, Caruso P, Morrell NW, Kovacic JC, Ulitsky I, Henderson NC, Caporali A, Leisegang MSBrandes RP, Baker AH. MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Circ Res. 2021 Apr 16;128(8):1173-1190. doi: 10.1161/CIRCRESAHA.120.318124.

 

Wack G, Metzner K, Kuth MS, Wang E, Bresnick A, Brandes RP, Schröder K, Wittig I, Schmidtko A, Kallenborn-Gerhardt W. Nox4-dependent upregulation of S100A4 after peripheral nerve injury modulates neuropathic pain processing. Free Radic Biol Med. 2021 Mar 28;168:155-167. doi: 10.1016/j.freeradbiomed.2021.03.021.

 

Delgado Lagos FA, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I (2021) Secreted modular calcium binding protein 1 binds/activates thrombin to account for platelet hyper-reactivity in diabetes. Blood 137 (12):1641-1651. doi: 10.1182/blood.2020009405.

 

Hesse M, Bednarz R, Carls E, Becker C, Bondareva O, Lother A, Geisen C, Dreßen M, Krane M, Roell W, Hein L, Fleischmann BK, Gilsbach R. Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. J Mol Cell Cardiol. 2021 Mar;152:95-104. doi: 10.1016/j.yjmcc.2020.11.012.

 

Warwick T, Schulz MH, Günther S, Gilsbach R, Neme A, Carlberg C, Brandes RP, Seuter S. A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep. 2021 Mar 22;11(1):6518. doi: 10.1038/s41598-021-86032-5.

 

Helfinger V, Freiherr von Gall F, Henke N, Kunze MM, Schmid T, Rezende F, Heidler J, Wittig I, Radeke HH, Marschall V, Anderson K, Shah AM, Fulda S, Brüne B, Brandes RP, Schröder K. Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2020152118. doi: 10.1073/pnas.2020152118.

 

Kyselova A, Zukunft S, Puppe D, Wittig I, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V (2021) Human platelets are a source of collagen I. Haematologica 106 (3):899-902. doi: 10.3324/haematol.2020.255612.

 

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I (2021) Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function. Circulation 143 (9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877 .

 

Fleming I (2021) A prickly situation: competitive antagonism by different hedgehog proteins. Cardiovascular Research: cvab037. doi: 10.1093/cvr/cvab037

 

Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z, Hu J, Fleming I, Wang DW (2021) Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduct Target Ther 6 (1):94. doi: 10.1038/s41392-020-00443-w .

 

Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmidt T, Fleming I, Fulda S, Weigert A (2021) Apoptotic cells induce proliferation of peritoneal macrophages. Int J Mol Sci. 22:2230. doi: 10.3390/ijms22052230 .

 

Hartmann M, Bibli SI, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E (2021) Combined cardioprotective and adipocyte browning effects promoted by the eutomer of dual sEH/PPARγ modulator. J Med Chem 64:2851-2828. doi: 10.1021/acs.jmedchem.0c02063 .

 

Kashefiolasl S, Leisegang MS, Helfinger V, Schürmann C, Pflüger-Müller B, Randriamboavonjy V, Vasconez AE, Carmeliet G, Badenhoop K, Hintereder G, Seifert V, Schröder K, Konczalla J, Brandes RP. Vitamin D-A New Perspective in Treatment of Cerebral Vasospasm. Neurosurgery. 2021 Feb 16;88(3):674-685. doi: 10.1093/neuros/nyaa484.

 

Huang J, Covic M, Huth C, Rommel M, Adam J, Zukunft S, Prehn C, Wang L, Nano J, Scheerer MF, Neschen S, Kastenmüller G, Gieger C, Laxy M, Schliess F, Adamski J, Suhre K, de Angelis MH, Peters A, Wang-Sattler R (2021) Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse. Metabolites 11 (2):89. doi: 10.3390/metabo11020089.

 

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S (2021) Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun 12 (1):681. doi: 10.1038/s41467-021-20905-1.

 

Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM (2021) EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep 22 (2):e48961. doi: 10.15252/embr.201948961.

 

Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W. GK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3.

 

Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, Müller A, Fehrenbacher B, Gonzalez-Menendez I, Quintanilla-Martinez L, Schröder KBrandes RP, Schaller M, Ruf W, Eichner M, Ghoreschi K, Röcken M, Pichler BJ, Kneilling M. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics. 2021 Jan 1;11(2):470-490. doi: 10.7150/thno.51462. eCollection 2021.

 

Schnelle M, Sawyer I, Anilkumar N, Mohamed BA, Richards DA, Toischer K, Zhang M, Catibog N, Sawyer G, Mongue-Din H, Schröder K, Hasenfuss G, Shah AM.  NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload. Cardiovasc Res. 2021 Jan 1;117(1):178-187. doi: 10.1093/cvr/cvz331.

 

Buchmann GK, Schürmann C, Spaeth M, Abplanalp W, Tombor L, John D, Warwick T, Rezende F, Weigert A, Shah AM, Hansmann ML, Weissmann N, Dimmeler S, Schröder K, Brandes RP. The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice. Redox Biol. 2021 Sep;45:102050. doi: 10.1016/j.redox.2021.102050. Epub 2021 Jun 18.PMID: 34218201