Latest Publications

2023

Boos F, Oo JA, Warwick T, Günther S, Izquierdo Ponce J, Lopez M, Rafii D, Buchmann G, Pham MD, Msheik ZS, Li T, Seredinski S, Haydar S, Kashefiolasl S, Plate KH, Behr R, Mietsch M, Krishnan J, Pullamsetti SS, Bibli SI, Hinkel R, Baker AH, Boon RA, Schulz MH, Wittig I, Miller FJ Jr, Brandes RP, Leisegang MS. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Basic Res Cardiol. 2023 Jan 26;118(1):5. doi: 10.1007/s00395-023-00978-3.PMID: 36700983 Free PMC article.

 

Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klöcker N, Kelm M, Schüttler D, Clauss S, Günther S, Boettger T, Braun T, Bär C, Pham MD, Krishnan J, Hille S, Müller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxán G, Dimmeler S. Aging impairs the neurovascular interface in the heart. Science. 2023 Aug 25;381(6660):897-906. doi: 10.1126/science.ade4961. Epub 2023 Aug 24.PMID: 37616346

 

Warwick T, Brandes RP, Leisegang MS.Noncoding RNA. Computational Methods to Study DNA:DNA:RNA Triplex Formation by lncRNAs. 2023 Jan 21;9(1):10. doi: 10.3390/ncrna9010010.PMID: 36827543 Free PMC article. Review.

 

Langschied F, Leisegang MS, Brandes RP, Ebersberger I. ncOrtho: efficient and reliable identification of miRNA orthologs. Nucleic Acids Res. 2023 Jul 21;51(13):e71. doi: 10.1093/nar/gkad467.PMID: 37260093 Free PMC article.

 

Roxlau ET, Pak O, Hadzic S, Garcia-Castro CF, Gredic M, Wu CY, Schäffer J, Selvakumar B, Pichl A, Spiegelberg D, Deutscher J, Bednorz M, Schäfer K, Kraut S, Kosanovic D, Zeidan EM, Kojonazarov B, Herold S, Strielkov I, Guenther A, Wilhelm J, Khalifa MMA, Taye A, Brandes RP, Hecker M, Grimminger F, Ghofrani HA, Schermuly RT, Seeger W, Sommer N, Weissmann N. Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations. Eur Respir J. 2023 Jun 22;61(6):2200951. doi: 10.1183/13993003.00951-2022. Print 2023 Jun.PMID: 37105573 Free PMC article.

 

Warwick T, Buchmann GK, Pflüger-Müller B, Spaeth M, Schürmann C, Abplanalp W, Tombor L, John D, Weigert A, Leo-Hansmann M, Dimmeler S, Brandes RP. Acute injury to the mouse carotid artery provokes a distinct healing response. Front Physiol. 2023 Feb 7;14:1125864. doi: 10.3389/fphys.2023.1125864. eCollection 2023.PMID: 36824462 Free PMC article.

 

Vogel A, Ueberbach T, Wilken-Schmitz A, Hahnefeld L, Franck L, Weyer MP, Jungenitz T, Schmid T, Buchmann G, Freudenberg F, Brandes RP, Gurke R, Schwarzacher SW, Geisslinger G, Mittmann T, Tegeder I. Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species. Cell Biosci. 2023 Aug 27;13(1):155. doi: 10.1186/s13578-023-01106-3.PMID: 37635256 Free PMC article.

 

Wu CY, Cilic A, Pak O, Dartsch RC, Wilhelm J, Wujak M, Lo K, Brosien M, Zhang R, Alkoudmani I, Witte B, Pedersen F, Watz H, Voswinckel R, Günther A, Ghofrani HA, Brandes RP, Schermuly RT, Grimminger F, Seeger W, Sommer N, Weissmann N, Hadzic S. CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD. Am J Respir Crit Care Med. 2023 Jun 15;207(12):1576-1590. doi: 10.1164/rccm.202208-1603OC.PMID: 37219322

 

Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K, Reinecke M, Heinzlmeir S, Leisegang MS, Wollenhaupt J, Lennartz F, Weiss MS, Kuster B, Tosato G, Schwalbe H. Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor. Chemistry. 2023 Apr 21;29(23):e202203967. doi: 10.1002/chem.202203967. Epub 2023 Mar 22.PMID: 36799129

 

Glaser SF, Brezski A, Baumgarten N, Klangwart M, Heumüller AW, Maji RK, Leisegang MS, Guenther S, Zehendner CM, John D, Schulz MH, Zarnack K, Dimmeler S. Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4.

Cell Rep. 2023 Aug 29;42(8):112824. doi: 10.1016/j.celrep.2023.112824. Epub 2023 Jul 22.PMID: 37481725 Free article.

 

Karger A, Mansouri S, Leisegang MS, Weigert A, Günther S, Kuenne C, Wittig I, Zukunft S, Klatt S, Aliraj B, Klotz LV, Winter H, Mahavadi P, Fleming I, Ruppert C, Witte B, Alkoudmani I, Gattenlöhner S, Grimminger F, Seeger W, Pullamsetti SS, Savai R. ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO J. 2023 Sep 18;42(18):e111620. doi: 10.15252/embj.2022111620. Epub 2023 Aug 7.PMID: 37545364 Free PMC article.

 

Vaca DJ, Frenzel F, Ballhorn W, Torres SG, Leisegang MS, Günther S, Bender D, Kraiczy P, Göttig S, Kempf VAJ. Adhesion of human pathogenic bacteria to endothelial cells is facilitated by fibronectin interaction. Microbes Infect. 2023 Sep-Oct;25(7):105172. doi: 10.1016/j.micinf.2023.105172. Epub 2023 Jun 19.PMID: 37343664 Free article.

 

van der Ven AT, Cabrera-Orefice A, Wente I, Feichtinger RG, Tsiakas K, Weiss D, Bierhals T, Scholle L, Prokisch H, Kopajtich R, Santer R, Mayr JA, Hempel M, Wittig I. Expanding the phenotypic and biochemical spectrum of NDUFAF3-related mitochondrial disease. Mol Genet Metab. 2023 Aug 4;140(3):107675. doi: 10.1016/j.ymgme.2023.107675. Online ahead of print.PMID: 37572574

 

Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L. Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression. Mol Ther. 2023 Jun 7;31(6):1775-1790. doi: 10.1016/j.ymthe.2023.04.020. Epub 2023 May 5.PMID: 37147804 Free article.

 

 

 

de Oliveira Freitas Machado C, Schafranek M, Brüggemann M, Hernández Cañás MC, Keller M, Di Liddo A, Brezski A, Blümel N, Arnold B, Bremm A, Wittig I, Jaé N, McNicoll F, Dimmeler S, Zarnack K, Müller-McNicoll M. Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia. Nucleic Acids Res. 2023 Jan 25;51(2):870-890. doi: 10.1093/nar/gkac1225.PMID: 36620874 Free PMC article.

 

Sych K, Nold SP, Pfeilschifter J, Vutukuri R, Meisterknecht J, Wittig I, Frank S, Goren I. Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro. J Mol Med (Berl). 2023 Feb;101(1-2):151-169. doi: 10.1007/s00109-022-02280-6. Epub 2023 Jan 12.PMID: 36633604 Free PMC article.

 

Nold SP, Sych K, Imre G, Fuhrmann DC, Pfeilschifter J, Vutukuri R, Schnutgen F, Wittig I, Meisterknecht J, Frank S, Goren I. Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediates gene editing in keratinocytes. FEBS J. 2023 May;290(9):2338-2365. doi: 10.1111/febs.16625. Epub 2022 Sep 24.PMID: 36083715

 

2022

Oo JA, Palfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, Tomaskovic I, Boos F, Izquierdo Ponce J, Teichmann T, Petriukov K, Haydar S, Maegdefessel L, Wu Z, Pham MD, Krishnan J, Baker AH, Günther S, Ulrich HD, Dikic I, Leisegang MS§, Brandes RP§. Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of replication protein A2. Cell Rep. 2022 Nov 15;41(7):111670. doi: 10.1016/j.celrep.2022.111670. PMID: 36384122.

 

Leisegang MS*, Bains JK*, Seredinski S, Oo JA, Krause NM, Kuo CC, Günther S, Sentürk Cetin N, Warwick T, Cao C, Boos F, Izquierdo Ponce J, Haydar S, Bednarz R, Valasarajan C, Fuhrmann D, Preussner J, Looso M, Pullamsetti SS, Schulz MH, Jonker HRA, Richter C, Rezende F, Gilsbach R, Pflüger-Müller B, Wittig I, Grummt I, Ribarska T, Costa IG, Schwalbe H§, Brandes RP§. HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. Nat Commun. 2022 Nov 2;13(1):6563. doi: 10.1038/s41467-022-34252-2. PMID: 36323673.

 

Warwick T, Seredinski S, Krause NM, Bains JK, Althaus L, Oo JA, Bonetti A, Dueck A, Engelhardt S, Schwalbe H, Leisegang  MS, Schulz MH§, Brandes RP§. A universal model of RNA·DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions. Brief Bioinform. 2022 Oct 13;bbac445. doi: 10.1093/bib/bbac445. PMID: 36239395.

 

Vaca DJ, Thibau A, Leisegang MS, Malmström J, Linke D, Eble JA, Ballhorn W, Schaller M, Happonen L, Kempf VAJ. Interaction of Bartonella henselae with Fibronectin Represents the Molecular Basis for Adhesion to Host Cells. Microbiol Spectr. 2022 Jun 29;10(3):e0059822. doi: 10.1128/spectrum.00598-22. PMID: 35435766.

 
Veith C, Vartürk-Özcan I, Wujak M, Hadzic S, Wu CY, Knoepp F, Kraut S, Petrovic A, Gredic M, Pak O, Brosien M, Heimbrodt M, Wilhelm J, Weisel FC, Malkmus K, Schäfer K, Gall H, Tello K, Kosanovic D, Sydykov A, Sarybaev A, Günther A, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Kwapiszewska G, Sommer N, Weissmann N. Circulation. SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension. 2022 Mar 22;145(12):916-933. doi: 10.1161/CIRCULATIONAHA.121.057001. Epub 2022 Feb 17.PMID: 35175782
 
Oo JABrandes RP, Leisegang MS. Long non-coding RNAs: novel regulators of cellular physiology and function. Pflugers Arch. 2022 Feb;474(2):191-204. doi: 10.1007/s00424-021-02641-z. Epub 2021 Nov 18.PMID: 34791525 
 
Brandes RP, Gründer S. Europhysiology 2022: bringing together the physiologists of Europe and the World : 16-18 September 2022, Tivoli Congress Center, Copenhagen, Denmark” as subtitle. Pflugers Arch. 2022 May;474(5):481-482. doi: 10.1007/s00424-022-02676-w.PMID: 35253088
 
Gredic M, Wu CY, Hadzic S, Pak O, Savai R, Kojonazarov B, Doswada S, Weiss A, Weigert A, Guenther A, Brandes RP, Schermuly RT, Grimminger F, Seeger W, Sommer N, Kraut S, Weissmann N. Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice. Eur Respir J. 2022 Apr 7;59(4):2101153. doi: 10.1183/13993003.01153-2021. Print 2022 Apr.PMID: 34475225 
 
Pliquett RU, Brandes RP. Experimental uninephrectomy associates with less parasympathetic modulation of heart rate and facilitates sodium-dependent arterial hypertension. PLoS One. 2022 Mar 9;17(3):e0265086. doi: 10.1371/journal.pone.0265086. eCollection 2022. PMID: 35263383 
 
Seredinski S, Boos F, Günther S, Oo JA, Warwick T, Izquierdo Ponce J, Lillich FF, Proschak E, Knapp S, Gilsbach R, Pflüger-Müller B, Brandes RP, LeisegangMS. DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells. Mol Ther Nucleic Acids. 2022 Jan 25;27:1023-1035. doi: 10.1016/j.omtn.2022.01.016. eCollection 2022 Mar 8.PMID: 35228897 
 
Warwick T, Schulz MH, Gilsbach RBrandes RP, Seuter S. Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763. doi: 10.1093/nar/gkac178. PMID: 35325193
 

2021

Lopez M, Malacarne PF, Gajos-Draus A, Ding X, Daiber A, Lundberg JO, Offermanns S, Brandes RP, Rezende F. Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. Br J Pharmacol. 2021 Apr;178(7):1495-1506. doi: 10.1111/bph.15362.

 

Monteiro JP, Rodor J, Caudrillier A, Scanlon JP, Spiroski AM, Dudnakova T, Pflüger-Müller B, Shmakova A, von Kriegsheim A, Deng L, Taylor RS, Wilson-Kanamori JR, Chen SH, Stewart K, Thomson A, Mitić T, McClure JD, Iynikkel J, Hadoke PWF, Denby L, Bradshaw AC, Caruso P, Morrell NW, Kovacic JC, Ulitsky I, Henderson NC, Caporali A, Leisegang MSBrandes RP, Baker AH. MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Circ Res. 2021 Apr 16;128(8):1173-1190. doi: 10.1161/CIRCRESAHA.120.318124.

 

Wack G, Metzner K, Kuth MS, Wang E, Bresnick A, Brandes RP, Schröder K, Wittig I, Schmidtko A, Kallenborn-Gerhardt W. Nox4-dependent upregulation of S100A4 after peripheral nerve injury modulates neuropathic pain processing. Free Radic Biol Med. 2021 Mar 28;168:155-167. doi: 10.1016/j.freeradbiomed.2021.03.021.

 

Delgado Lagos FA, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I (2021) Secreted modular calcium binding protein 1 binds/activates thrombin to account for platelet hyper-reactivity in diabetes. Blood 137 (12):1641-1651. doi: 10.1182/blood.2020009405.

 

Hesse M, Bednarz R, Carls E, Becker C, Bondareva O, Lother A, Geisen C, Dreßen M, Krane M, Roell W, Hein L, Fleischmann BK, Gilsbach R. Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. J Mol Cell Cardiol. 2021 Mar;152:95-104. doi: 10.1016/j.yjmcc.2020.11.012.

 

Warwick T, Schulz MH, Günther S, Gilsbach R, Neme A, Carlberg C, Brandes RP, Seuter S. A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep. 2021 Mar 22;11(1):6518. doi: 10.1038/s41598-021-86032-5.

 

Helfinger V, Freiherr von Gall F, Henke N, Kunze MM, Schmid T, Rezende F, Heidler J, Wittig I, Radeke HH, Marschall V, Anderson K, Shah AM, Fulda S, Brüne B, Brandes RP, Schröder K. Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2020152118. doi: 10.1073/pnas.2020152118.

 

Kyselova A, Zukunft S, Puppe D, Wittig I, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V (2021) Human platelets are a source of collagen I. Haematologica 106 (3):899-902. doi: 10.3324/haematol.2020.255612.

 

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I (2021) Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function. Circulation 143 (9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877 .

 

Fleming I (2021) A prickly situation: competitive antagonism by different hedgehog proteins. Cardiovascular Research: cvab037. doi: 10.1093/cvr/cvab037.

 

Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z, Hu J, Fleming I, Wang DW (2021) Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduct Target Ther 6 (1):94. doi: 10.1038/s41392-020-00443-w.

 

Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmidt T, Fleming I, Fulda S, Weigert A (2021) Apoptotic cells induce proliferation of peritoneal macrophages. Int J Mol Sci. 22:2230. doi: 10.3390/ijms22052230.

 

Hartmann M, Bibli SI, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E (2021) Combined cardioprotective and adipocyte browning effects promoted by the eutomer of dual sEH/PPARγ modulator. J Med Chem 64:2851-2828. doi: 10.1021/acs.jmedchem.0c02063.

 

Kashefiolasl S, Leisegang MS, Helfinger V, Schürmann C, Pflüger-Müller B, Randriamboavonjy V, Vasconez AE, Carmeliet G, Badenhoop K, Hintereder G, Seifert V, Schröder K, Konczalla J, Brandes RP. Vitamin D-A New Perspective in Treatment of Cerebral Vasospasm. Neurosurgery. 2021 Feb 16;88(3):674-685. doi: 10.1093/neuros/nyaa484.

 

Huang J, Covic M, Huth C, Rommel M, Adam J, Zukunft S, Prehn C, Wang L, Nano J, Scheerer MF, Neschen S, Kastenmüller G, Gieger C, Laxy M, Schliess F, Adamski J, Suhre K, de Angelis MH, Peters A, Wang-Sattler R (2021) Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse. Metabolites 11 (2):89. doi: 10.3390/metabo11020089.

 

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S (2021) Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun 12 (1):681. doi: 10.1038/s41467-021-20905-1.

 

Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM (2021) EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep 22 (2):e48961. doi: 10.15252/embr.201948961.

 

Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W. GK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3.

 

Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, Müller A, Fehrenbacher B, Gonzalez-Menendez I, Quintanilla-Martinez L, Schröder KBrandes RP, Schaller M, Ruf W, Eichner M, Ghoreschi K, Röcken M, Pichler BJ, Kneilling M. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics. 2021 Jan 1;11(2):470-490. doi: 10.7150/thno.51462. eCollection 2021.

 

Schnelle M, Sawyer I, Anilkumar N, Mohamed BA, Richards DA, Toischer K, Zhang M, Catibog N, Sawyer G, Mongue-Din H, Schröder K, Hasenfuss G, Shah AM.  NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload. Cardiovasc Res. 2021 Jan 1;117(1):178-187. doi: 10.1093/cvr/cvz331.

 

Buchmann GK, Schürmann C, Spaeth M, Abplanalp W, Tombor L, John D, Warwick T, Rezende F, Weigert A, Shah AM, Hansmann ML, Weissmann N, Dimmeler S, Schröder K, Brandes RP. The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice. Redox Biol. 2021 Sep;45:102050. doi: 10.1016/j.redox.2021.102050. Epub 2021 Jun 18.PMID: 34218201 
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